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Opinion|Videos|April 28, 2025

Treatment Planning for HER2+ Breast Cancer: The Role of Ovarian Function Suppression

Author(s)Kelly E. McCann, MD, PhD, Gregory Vidal, MD, PhD

Panelists discuss how ovarian suppression combined with endocrine therapy shows benefits for premenopausal patients with triple-positive breast cancer, particularly in younger, high-risk populations.

Episodes in this series

2 experts in this video

EP. 1 Optimizing Therapy in HR+/HER2+ Breast Cancer: Balancing Endocrine, HER2-Targeted, and Chemotherapy Options

2 experts in this video

EP. 2 Treatment Planning for HER2+ Breast Cancer: The Role of Ovarian Function Suppression

2 experts in this video

EP. 3 HER2+ Breast Cancer Management: Navigating GnRH Agonist Choice and Patient Experience

2 experts in this video

EP. 4 Navigating Early-Line Treatment Options for HER2+ Metastatic Breast Cancer

2 experts in this video

EP. 5 Expert Insights on Third-Line Treatment Decisions for HER2+ Metastatic Breast Cancer

2 experts in this video

EP. 6 Navigating the Data: Later-Line Systemic Therapies for HER2+ Metastatic Breast Cancer

2 experts in this video

EP. 7 Patient-Centered Decisions and Evolving Treatment Landscape for HER2+ Metastatic Breast Cancer

Video content above is prompted by the following:

Fertility Preservation and Ovarian Suppression

Key Themes:

Ovarian suppression recommendations
- Based on SOFT/TEXT trial data, showing benefit for high-risk premenopausal patients
- Particularly beneficial for patients under 35 years of age
- Recommended for patients receiving chemotherapy or considered high risk
- HER2-positive patients may benefit from ovarian suppression
HERA trial analysis
- Recent analysis presented at ESMO 2024 examined premenopausal women with triple-positive breast cancer
- Found survival outcomes of ovarian function suppression plus aromatase inhibitor superior to ovarian function suppression plus tamoxifen
- Ovarian function suppression combined with endocrine therapy was superior to tamoxifen alone

Notable Insights:

Dr Vidal shared: “For my premenopausal hormone receptor–positive patients for whom I think there’s high risk, those patients, I definitely add ovarian suppression.”
Dr McCann emphasized: “I always tell my patients that my favorite medication for them is the one they’re willing to take.”

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