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DDR Alterations Associated With Increased Anti-PD-1/PD-L1 Activity in Bladder Cancer

Jason Harris
Published: Thursday, Mar 01, 2018

Jonathan E. Rosenberg, MD

Jonathan E. Rosenberg, MD
Alterations in DNA damage response and repair (DDR) genes were associated with an increased response to anti-PD-1/PD-L1 antibodies in patients with metastatic urothelial carcinoma, according to findings published in the Journal of Clinical Oncology.

Additional multivariable analyses for PFS and OS with mutation load in place of DDR status, stratification by DDR status, and stratification by mutation load showed that DDR-containing models remained a superior predictor of outcomes compared with mutation load.
Teo MY, Seier K, Ostrovnaya I, et al. Alterations in DNA damage response and repair genes as potential marker of clinical benefit from PD-1/PD-L1 blockade in advanced urothelial cancers [published online February 28, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017. 75.7740.

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