Paul E. Oberstein, MD
Although new agents have demonstrated benefit in the treatment of patients with advanced pancreatic neoplasms, outcomes remain poor, said Paul E. Oberstein, MD. In the United States, about 50% of patients with metastatic pancreatic adenocarcinoma will die within 2 months of diagnosis. Additionally, 50% of elderly patients never receive any therapy.
In a presentation at the 2018 OncLive®
State of the Science Summit™ on Gastrointestinal Cancers, Oberstein, director of Gastrointestinal Medical Oncology at NYU Langone’s Perlmutter Cancer Center, discussed incorporating novel agents and sequencing approaches in advanced pancreatic neoplasms.
With investigative therapies in the pipeline, questions remain about how to incorporate and sequence these newer agents in this treatment paradigm.
"We desperately need to figure out how to bring new agents to the clinic and how to use them rationally," said Oberstein. "We need to do better."
Gemcitabine was approved more than 20 years ago for the treatment of patients with advanced pancreatic cancer. Beyond that, there have only been 3 positive studies that have defined new treatments for pancreatic cancer.
More data are needed, Oberstein explained. There is limited information to guide treatment decisions for patients with locally advanced disease, and there are no large controlled studies looking at neoadjuvant regimens, he added.
In 2011, data on FOLFIRINOX as a first-line treatment for patients with advanced pancreatic cancer was published in the New England Journal of Medicine
FOLFIRINOX was compared with gemcitabine alone in patients with advanced metastatic pancreatic cancer who were high performing.
Response rates went from 9.4% with gemcitabine to 31.6% with FOLFIRINOX. Median overall survival (OS) with FOLFIRINOX was 11.1 months compared with 6.8 months with gemcitabine. Moreover, median progression-free survival (PFS) was also superior with FOLFIRINOX at 6.4 months versus gemcitabine at 3.3 months. The success of this therapy came with increased toxicities; however, for patients who could tolerate FOLFIRINOX, quality of life was improved. FOLFIRINOX is now a standard frontline therapy for advanced pancreatic adenocarcinoma.
In 2013, a study on the combination of gemcitabine and nab-paclitaxel (Abraxane) as a first-line therapy for the general population of untreated metastatic patients was published in NEJM.2
This study showed a response rate of 23% with gemcitabine and nab-paclitaxel versus 7% with gemcitabine alone, according to independent review. Additionally, median PFS with the combination was 5.5 months versus 3.7 months with gemcitabine monotherapy, and the median OS was 8.5 months and 6.7 months, respectively. Similar to FOLFIRINOX, patients treated with gemcitabine plus nab-paclitaxel had increased toxicities.
A third study, the NAPOLI-1 trial, was published in 2015 in Lancet, and evaluated the combination of nanoliposomal irinotecan plus fluorouracil and folinic acid versus fluorouracil and folinic acid in the second-line setting.3
Patients in this study had failed first-line gemcitabine therapy and were randomized to 1 of the 2 arms.
The response rate of single-agent therapy was minimal at 1%, while the response rate with the combination of nanoliposomal irinotecan plus fluorouracil and folinic acid was 16%. Median PFS and OS were both modestly in favor of the combination, but still significant, said Oberstein. This combination was not compared with other regimens.
"These are 3 positive studies that have changed practice," said Oberstein. "[These therapies] are being used now widely in the clinic and have a very positive impact on our patients’ outcomes for advanced pancreatic cancer."
Addressing the fact that there are a limited amount of data, Oberstein said that it is not for a lack of trying.
"There have been tremendous efforts to find better therapies for advanced pancreatic cancers, but there are reasons they have failed, be it luck or design," explained Oberstein. "Learning those lessons will help us do better."
Efforts currently are being directed toward finding treatments for patients with locally advanced disease. The answer to this unmet need lies in comparative trials, Oberstein suggested.
For example, the ongoing S1505 trial is evaluating perioperative therapy in resectable patients with pancreatic adenocarcinoma (NCT02562716). Specifically, the study is comparing perioperative mFOLFIRINOX with gemcitabine/nab-paclitaxel in patients with resectable pancreatic adenocarcinoma. Oberstein said that it is both addressing an important question and utilizing standard agents, but it is not directly comparing the 2 regimens. Therefore, it may not yield conclusive data.