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Expert Highlights Potential of Erdafitinib in Urothelial Carcinoma

Brandon Scalea
Published: Friday, Aug 10, 2018

Arlene O. Siefker-Radtke, MD
Arlene O. Siefker-Radtke, MD
Erdafitinib, a novel pan-FGFR inhibitor, demonstrated promising activity in patients with urothelial cancer who harbor FGFR alterations, according to recent data from a phase II trial.

, Siefker-Radtke, associate professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, clinical co-leader, Bladder Spore Executive Committee, discussed the promise of erdafitinib in patients with urothelial carcinoma.

OncLive: Please provide some background for this trial.

Siefker-Radtke: Bladder cancer is really no longer just one disease. We have been treating it that way for several decades now. What we are learning is that there are different types of bladder cancers, some that respond better to chemotherapy, some that respond better to immunotherapy, and some that appear immunologically cold. In fact, the FDA just announced they are no longer accruing patients with low PD-L1 expression to the frontline single-agent immunotherapy trials. Therefore, there is growing evidence that we need more options for our patients with bladder cancer.
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