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FDA Expands Pemetrexed Approval for Frontline Pembrolizumab/Chemo Combo in NSCLC

Gina Columbus @ginacolumbusonc
Published: Thursday, Jan 31, 2019

Anne White

Anne White
The FDA has expanded the indication for pemetrexed (Alimta) injection in combination with pembrolizumab (Keytruda) and platinum-based chemotherapy for the first-line treatment of patients with metastatic nonsquamous non–small cell lung cancer (NSCLC) without EGFR or ALK alterations.1

The updated indication is based on data from the phase III KEYNOTE-189 trial, which was the basis for the FDA’s full approval of frontline pembrolizumab for use in combination with standard chemotherapy for patients with metastatic nonsquamous NSCLC.2,3

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