Tim Van den Wyngaert, MD, PhD
Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) scanning reliably detected residual neck disease in newly diagnosed patients with locoregionally advanced head-and-neck squamous cell carcinoma (LAHNSCC).
The largest residual lymph node per patient as measured on the CT part of the 12-week PET/CT study had median short axis diameters of in Hopkins-negative patients 6 mm (IQR, 3 mm) and 8 mm (IQR, 3.5 mm) in Hopkins-positive. The proportion of misclassified among patients with a negative Hopkins neck score increased when residual lymph node size criteria or the presence of necrosis were applied. There was no significant improvement in misclassification rate with the addition of lymph node size or necrosis in patients with a positive Hopkins neck score, though the small size for that population scores (n = 24) made it difficult to draw conclusions from that observation.
Van den Wyngaert T, Helsen N, Carp L, et al. Fluorodeoxyglucose-positron emission tomography/computed tomography after concurrent chemoradiotherapy in locally advanced head-and-neck squamous cell cancer: The ECLYPS study [published online August 30, 2017]. J Clin Oncol. doi: 10.1200/JCO.2017.73.5845.
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