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Frontline Maintenance Olaparib Approved in Europe for Ovarian Cancer

Gina Columbus @ginacolumbusonc
Published: Tuesday, Jun 18, 2019

Dave Fredrickson

Dave Fredrickson

The European Commission has approved olaparib (Lynparza) as a single agent for the maintenance treatment of adult patients with advanced BRCA1/2-mutated germline and/or somatic high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response (PR) following first-line platinum-based chemotherapy.1

The approval is based on findings from the double-blind, phase III SOLO-1 trial, in which maintenance olaparib led to a 70% reduction in the risk of disease progression or death compared with placebo in patients with BRCA-mutant advanced ovarian cancer after completing frontline platinum-based chemotherapy (HR, 0.30; 95% CI, 0.23-0.41; P <.001).2,3

The FDA approved olaparib for this indication in December 2018.

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