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Lead Investigator Highlights ECHELON-1 Lymphoma Data From North American Subgroup

Caroline Seymour
Published: Thursday, Sep 27, 2018

Radhakrishnan Ramchandren, MD

Radhakrishnan Ramchandren, MD
The North American subgroup analysis of the phase III ECHELON-1 trial revealed more than double the improvement seen with brentuximab vedotin (Adcetris) plus doxorubicin, vinblastine, and dacarbazine (A+AVD) compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) versus the primary study findings in patients with advanced Hodgkin lymphoma, explained lead author Radhakrishnan Ramchandren, MD.

In the interview, Ramchandren, associate professor, Wayne State University School of Medicine, Karmanos Cancer Institute, gave an overview of the treatment landscape in Hodgkin and T-cell lymphoma before delving into the results of the North American subgroup analysis of the ECHELON-1 trial.

OncLive: Can you provide an overview of your lectures on Hodgkin lymphoma and T-cell lymphoma?

Ramchandren: Hodgkin lymphoma is a disease that occurs in young individuals. It has been a landmark condition because we have historically had early success in treating it. However, this has come at the cost of toxicities—both acute and long-term—for patients who survive. There are patients who unfortunately don't respond to standard chemotherapy and radiation and relapse. For those patients, autologous stem cell transplant (ASCT) is an option. However, some of those patients can't achieve a remission and go to transplant or are unable to go to transplant for other reasons. For those individuals, expectations are very short in terms of lifespan and quality of life.
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