An adjusted combination of chemotherapy, radiation therapy, and surgery induced a 5-year overall survival (OS) rate of 91.3% in pediatric patients with rhabdomyosarcomas (RMS) of the head and neck.
Common side effects associated with chemotherapy and radiation therapy included neutropenia, mucositis, nausea and vomiting, and radiodermatitis. One patient had a secondary malignancy, a radiation-induced sarcoma of the right pterygopalatine fossa treated with ifosfamide, topotecan, and cyclophosphamide.
Häußler SM, Stromberger C, Olze, et al. Head and neck rhabdomyosarcoma in children: a 20-year retrospective study at a tertiary referral center [published online November 16, 2017]. J Cancer Res Clin Oncol. doi: 10.1007/s00432-017-2544-x.
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