Georgina V. Long, BSc, PhD, MBBS
The combination of nivolumab (Opdivo) and ipilimumab (Yervoy) induced an intracranial response of 46% in melanoma patients with asymptomatic, untreated brain metastases. The intracranial response rate (ICR) with nivolumab monotherapy was 20%.
There were no deaths attributed to the study treatment. Nine (26%) patients in cohort A, one (4%) in cohort B, and 1 (6%) in cohort C discontinued study treatment due to AEs.
Long GV, Atkinson V, Lo S, et al. Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicenter randomised phase 2 study [published online March 27, 2018]. Lancet Oncol. doi: 10.1016/ S1470-2045(18)30139-6.
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