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O'Regan Assesses Treatment Courses and Durations in Early-Stage HR+ Breast Cancer

Caroline Seymour
Published: Thursday, Jun 20, 2019

Dr. Ruth O'Regan

Ruth O'Regan, MD

There are several genomic assays and corresponding data sets that physicians can use to assess the risk of recurrence for a patient with early-stage hormone receptor (HR)–positive, HER2-negative breast cancer and their need for chemotherapy or endocrine therapy alone.

However, because a lot of these data fall short in terms of extended endocrine therapy and patients with node-positive disease, physicians should err on the side of caution when it comes to higher-risk patients until those results read out, explained Ruth O’Regan, MD.

“The use of genomic subtyping in early-stage estrogen receptor (ER)–positive breast cancer has really allowed us to make much more robust decisions for our patients. We've made huge strides in avoiding chemotherapy for patients with early-stage ER-positive breast cancer,” said O’Regan. “The remaining questions are, ‘How do we manage patients with node-positive disease? For premenopausal patients, can we get away with ovarian suppression rather than chemotherapy? Who are the patients who need longer durations of endocrine therapy?’”

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