Manju P. Paul, MD
Advancements in bronchoscopic techniques have allowed pulmonologists to better diagnose patients who present with lung nodules, explained Manju P. Paul, MD.
Findings from the NELSON trial demonstrated that the use of CT screening resulted in a 26% reduction in lung cancer deaths in asymptomatic men at 10 years of follow-up (95% CI, 9%-41%). Results presented at the 19th World Conference on Lung Cancer also indicated that the benefit was more compelling in women, who accounted for approximately 20% of the study population.
The population-based controlled trial enrolled 15,792 individuals who were randomized 1:1 to the study arm or the control arm; those in the study arm were offered CT screening, whereas those in the control arm were not. Results of the study demonstrated an 86% average CT screening compliance rate, totaling 29,736 scans. Sixty-nine percent of screen-detected lung cancers were found to be stage Ia or Ib. Additionally, more than half of patients in the study arm were eligible for surgical treatment versus fewer than one-quarter of those in the control arm (67.7% vs 24.5%; P <.001).
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