Jeffrey S. Dome, MD, PhD
A novel risk stratification and treatment approach led to enhanced clinical outcomes overall, as well as the successful omission of radiotherapy (RT) for some patients with stage IV favorable histology Wilms tumor and pulmonary metastases, according to findings from the COG AREN0533 published in the Journal of Clinical Oncology.
Twelve patients reported 22 adverse events (AEs)—8 in the DD4A group and 14 in the Regimen M group. One patient in the DD4A group died due to surgical complications within the first 6 weeks, and 1 patient receiving Regimen M died of undetermined cause. Investigators found that the rate of grade ≥3 nonhematologic AEs was low in the Regimen M group, the most common being infections and infestations (14.1%) and hypokalemia (5.4%).
Dix DB, Seibel NL, Chi YY, et al. Treatment of stage IV favorable histology Wilms tumor with lung metastases: a report from the Children’s Oncology Group AREN0533 study [published online April 16, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017.77.1931.
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