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Study Finds No Cardiac Toxicity Increase With Trastuzumab in HER2+ Breast Cancer Patients

Jason Harris
Published: Wednesday, Jan 17, 2018

Patricia A. Ganz, MD

Patricia A. Ganz, MD
Trastuzumab (Herceptin) did not reduce cardiac function in women with node-positive, HER2+, early-stage breast cancer, according to long-term follow-up (LTF) results from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-31 trial published in the Journal of Clinical Oncology.

“Our study improved the 10-year survival for women with this type of aggressive breast cancer to 84% and now our long-term follow-up of how these women are doing provides positive and encouraging data specifically about their cardiac function and health,” co-author Edward Romond, MD, professor, University of Kentucky Markey Cancer Center, said in a press release.
Ganz PA, Romond EH, Cecchini RS, et al. Long-term follow-up of cardiac function and quality of life for patients in NSABP protocol B-31/NRG Oncology: A randomized trial comparing the safety and efficacy of doxorubicin and cyclophosphamide (ac) followed by paclitaxel with AC followed by paclitaxel and trastuzumab in patients with node-positive breast cancer with tumors overexpressing human epidermal growth factor receptor 2. J Clin Oncol. 2017;35:3942-3948.

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TitleExpiration DateCME Credits
Real-World Evidence to Inform Treatment and Management of ER+ Metastatic Breast CancerDec 31, 20191.0
Medical Crossfire®: A Critical Assessment of Current and Emerging Data Sets to Move Treatment of Triple-Negative Breast Cancer ForwardJan 31, 20201.0
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