Dr. Dummer on NEMO Trial for NRAS-Mutant Melanoma

Reinhard Dummer, MD
Published: Tuesday, Jun 07, 2016

Reinhard Dummer, MD, professor, Department of Dermatology, University of Zurich Hospital, discusses the results of the phase III NEMO trial, which compared the efficacy of binimetinib with dacarbazine in patients with NRAS-mutant metastatic melanoma.

In the study, patients were randomized to receive the combination of the MEK inhibitor binimetinib and dacarbazine or dacarbazine alone. The combination arm demonstrated a significant improvement in progression-free survival (PFS), with a hazard ratio of 0.62, Dummer explains.

In a separate analysis that examined the efficacy of the combination in patients who were previously treated with an immunotherapy agent, the benefit was higher than in the overall patient population. In these patients, the median progression-free survival was 5.5 months versus 1.6 months with the combination and dacarbazine alone, respectively.

These findings demonstrate binimetinib's potential as an alternative treatment options for patients with NRAS-mutant melanoma.

<<< View more from the 2016 ASCO Annual Meeting

Reinhard Dummer, MD, professor, Department of Dermatology, University of Zurich Hospital, discusses the results of the phase III NEMO trial, which compared the efficacy of binimetinib with dacarbazine in patients with NRAS-mutant metastatic melanoma.

In the study, patients were randomized to receive the combination of the MEK inhibitor binimetinib and dacarbazine or dacarbazine alone. The combination arm demonstrated a significant improvement in progression-free survival (PFS), with a hazard ratio of 0.62, Dummer explains.

In a separate analysis that examined the efficacy of the combination in patients who were previously treated with an immunotherapy agent, the benefit was higher than in the overall patient population. In these patients, the median progression-free survival was 5.5 months versus 1.6 months with the combination and dacarbazine alone, respectively.

These findings demonstrate binimetinib's potential as an alternative treatment options for patients with NRAS-mutant melanoma.

<<< View more from the 2016 ASCO Annual Meeting


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Evolving Roles for Targeted Melanoma Therapies: Assessing Rapid Progress in the Field and Looking Toward Future CombinationsFeb 28, 20191.5
Advances in™ Melanoma: Exploring BRAF/MEK in Adjuvant and Neoadjuvant SettingsSep 28, 20191.5
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