Robert L. Fine, MD, an associate professor of Medicine at New York Presbyterian Hospital-Columbia University Medical Center, discusses the prospective phase II study of CAPTEM (capecitabine and temozolomide) for patients with neuroendocrine tumors.
Fine says the results of the trial showed tremendous responses in every neuroendocrine tumor. The treatment elicited a response rate of 45% and a stable disease rate of 52%.
Carcinoids, which represents that majority of all neuroendocrine tumors and normally have a response rate of 0%-4%, showed a 45% response rate in this study, Fine says.
Moreover, Fine points out, the CAPTEM combination is extremely nontoxic. There were no grade 4 toxicities and only 10-15% grade 3 toxicities, with the most common grade 3 toxicity being lymphopenia.
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