Dr. Hurvitz on Eliminating Anthracyclines in HER2+ Breast Cancer Treatment

Sara Hurvitz, MD
Published: Friday, Mar 10, 2017


Sara Hurvitz, MD, Associate Professor of Medicine at UCLA, discusses data supporting the elimination of anthracyclines in HER2-positive breast cancer treatment.
 
HER2-targeted therapy has significantly improved disease-free and overall survival in the adjuvant setting, with trastuzumab (Herceptin) altering the natural history of the disease. However, Hurvitz explains, the agent comes with the risk of cardiac toxicity. It is unknown if the combination of trastuzumab plus anthracyclines is causing long-term cardiac event rates to increase in these patients.
 
There are a few non-anthracycline regimens that have been evaluated in the adjuvant setting, with the results showing significantly fewer cardiac events and less cardiac toxicity than the anthracycline-containing regimen, Hurvitz says. The promise is that these regimens will be associated with less cardiac toxicity long-term for these patients.

<<< View more from the 2017 Miami Breast Cancer Conference

Sara Hurvitz, MD, Associate Professor of Medicine at UCLA, discusses data supporting the elimination of anthracyclines in HER2-positive breast cancer treatment.
 
HER2-targeted therapy has significantly improved disease-free and overall survival in the adjuvant setting, with trastuzumab (Herceptin) altering the natural history of the disease. However, Hurvitz explains, the agent comes with the risk of cardiac toxicity. It is unknown if the combination of trastuzumab plus anthracyclines is causing long-term cardiac event rates to increase in these patients.
 
There are a few non-anthracycline regimens that have been evaluated in the adjuvant setting, with the results showing significantly fewer cardiac events and less cardiac toxicity than the anthracycline-containing regimen, Hurvitz says. The promise is that these regimens will be associated with less cardiac toxicity long-term for these patients.

<<< View more from the 2017 Miami Breast Cancer Conference

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Chicago: Advances in the Treatment of Breast CancerJul 31, 20181.0
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
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