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Drs. Elias Jabbour and Michael Mauro discuss how patient comorbidities influence the selection of frontline tyrosine kinase inhibitor (TKI) therapy in chronic phase CML, highlighting specific comorbidity-TKI combinations to avoid and strategies for optimizing individualized treatment.
Panelists discuss the importance of achieving deep molecular response in chronic myeloid leukemia (CML) as both a clinical milestone and a patient-centered goal, highlighting its role in reducing relapse risk, enabling treatment-free remission, and aligning medical outcomes with patients’ desire for a functional cure and improved quality of life.
Panelists discuss the complexities of selecting frontline therapy for chronic myeloid leukemia (CML), emphasizing the need to balance efficacy, adverse effect profiles, dose management strategies, and financial considerations to ensure long-term disease control, patient adherence, and quality of life.
Panelists discuss the individualized selection of tyrosine kinase inhibitors (TKIs) in a high-risk chronic myeloid leukemia case, highlighting how comorbidities, risk scores, and long-term goals such as treatment-free remission influence frontline therapy decisions to balance efficacy, safety, and quality of life.
Panelists discuss the importance of evaluating and communicating the adverse effect profiles of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia, emphasizing how day-to-day tolerability, comorbidities, and patient preferences inform personalized treatment selection to support adherence and quality of life.
Panelists discuss the importance of understanding adverse event profiles and patient-specific risk factors in selecting chronic myeloid leukemia (CML) therapies, emphasizing personalized treatment approaches that balance efficacy with tolerability to optimize long-term adherence and quality of life.
Panelists discuss the critical role of open communication and patient partnership in managing adverse events during treatment, highlighting proactive education, dose adjustments, and collaborative care strategies to enhance adherence, quality of life, and long-term outcomes in chronic disease management.
Panelists discuss the critical impact of treatment adherence and intolerance on outcomes in chronic myeloid leukemia (CML), emphasizing compassionate communication, patient education, and proactive management of adverse effects to support sustained therapy, improve quality of life, and achieve long-term remission goals.
Panelists highlight that early communication about treatment-free remission (TFR), personalized therapy selection, and proactive management of adverse effects are key to motivating adherence and achieving long-term remission in chronic myeloid leukemia (CML).
Panelists emphasize that eligibility for treatment discontinuation in chronic myeloid leukemia (CML) is individualized, balancing clinical factors with patient preferences and readiness through shared decision-making and ongoing support.
Experts emphasize that achieving early and deep molecular responses—such as MMR and MR4.5—is key to identifying patients most likely to reach treatment-free remission, but careful interpretation of molecular fluctuations, patient education, and the development of better biomarkers remain essential for optimizing discontinuation strategies in CML care.
Panelists note that treatment discontinuation in patients with sustained deep remission typically follows complete cessation after several years, with stepwise dose de-escalation serving as an option for those facing adverse effects or adherence challenges, emphasizing individualized decisions based on patient goals and careful monitoring.
Panelists conclude on an optimistic note, highlighting that advances in therapy and collaborative care have transformed chronic-phase chronic myeloid leukemia (CP-CML) into a highly manageable disease with improved outcomes, treatment-free remission (TFR) possibilities, and a promising future marked by continued progress and patient-centered care.
An expert discusses how patient-specific goals influence frontline treatment decisions in CP-CML, emphasizing the unique efficacy and safety profile of asciminib compared to second-generation TKIs and identifying potential subgroups who may benefit most from its use.
An expert discusses how managing treatment-related toxicities—especially fatigue, musculoskeletal pain, GI symptoms, and cardiovascular events—is critical in CP-CML, highlighting strategies such as dose adjustments, supportive care, and selecting better-tolerated TKIs like asciminib to improve adherence and patient outcomes.
An expert discusses how treatment-free remission (TFR) in CP-CML is achievable for a carefully selected subset of patients with sustained deep molecular response, emphasizing the importance of individualized decision-making, close molecular monitoring post-discontinuation, and the reassuring ability to regain response upon TKI reinitiation if relapse occurs.
