In this video, Neal D. Shore, MD, FACS, and Rana R. McKay, MD, FASCO, discuss the evolving treatment landscape for metastatic hormone-sensitive prostate cancer and the clinical rationale for evaluating darolutamide (Nubeqa) plus ADT in a US patient population.
Rana R. McKay, MD, FASCO, and Neal D. Shore, MD, FACS, explain ARASEC's use of a synthetic historical control arm derived from the CHAARTED trial, a design approach they describe as both ethically necessary and methodologically efficient.
In this segment, Rana R. McKay, MD, FASCO, and Neal D. Shore, MD, FACS, detail the 6 prognostic variables used for propensity score matching, the mechanics of 1:1 patient pairing, and the practical advantages of the ARASEC design over a large randomized phase 3 trial.
Neal D. Shore, MD, FACS, and Rana R. McKay, MD, FASCO, present the primary rPFS and key secondary OS results from ARASEC and contextualize the findings within the broader darolutamide (Nubeqa) evidence base.
In this video, Neal D. Shore, MD, FACS, and Rana R. McKay, MD, FASCO, address the clinical positioning of darolutamide (Nubeqa) plus ADT in mHSPC, the favorable safety profile of darolutamide, and the importance of multidisciplinary involvement in prostate cancer management.
