Dr. Andre on Nivolumab Plus Ipilimumab in dMMR/MSI-H mCRC

Thierry Andre, MD
Published: Wednesday, Jan 24, 2018



Thierry Andre, MD, professor of medical oncology, University Pierre et Marie Curie (UMPC), and Head of the Medical Oncology Department in St. Antoine Hospital, Assistance Publique Hôpitaux de Paris, discusses the results of the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC).

In the first report of the full cohort from the CheckMate-142 study at the 2018 Gastrointestinal Cancer Symposium, investigators conclude that the combination of nivolumab and ipilimumab built on the efficacy reported with nivolumab monotherapy. This resulted in enhanced clinical benefit with a manageable safety profile.

Patients on the study received nivolumab at 3 mg/kg and ipilimumab at 1 mg/kg every 3 weeks for 4 doses followed by nivolumab monotherapy at 3 mg/kg every 2 weeks.

Of 119 patients with dMMR/MSI-H mCRC, the overall response rate was 55% and disease control rate was 80% at 12 weeks, says Andre. Additionally, the 9-month progression-free survival was 76%, and the overall response rate was 87%. This combination may represent a new standard of care for this population of patients.


Thierry Andre, MD, professor of medical oncology, University Pierre et Marie Curie (UMPC), and Head of the Medical Oncology Department in St. Antoine Hospital, Assistance Publique Hôpitaux de Paris, discusses the results of the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC).

In the first report of the full cohort from the CheckMate-142 study at the 2018 Gastrointestinal Cancer Symposium, investigators conclude that the combination of nivolumab and ipilimumab built on the efficacy reported with nivolumab monotherapy. This resulted in enhanced clinical benefit with a manageable safety profile.

Patients on the study received nivolumab at 3 mg/kg and ipilimumab at 1 mg/kg every 3 weeks for 4 doses followed by nivolumab monotherapy at 3 mg/kg every 2 weeks.

Of 119 patients with dMMR/MSI-H mCRC, the overall response rate was 55% and disease control rate was 80% at 12 weeks, says Andre. Additionally, the 9-month progression-free survival was 76%, and the overall response rate was 87%. This combination may represent a new standard of care for this population of patients.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Oncology Best Practice™: Choosing Therapies for Patients with EGFR-mutant Lung Cancers: More Options... More Decisions... Better OutcomesApr 27, 20182.0
Community Practice Connections™: 21st Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas, and MyelomaApr 27, 20182.0
Publication Bottom Border
Border Publication
x