Dr. Bauml on HPV Vaccination for Head and Neck Cancer

Joshua Bauml, MD
Published: Wednesday, Feb 21, 2018



Joshua Bauml, MD, assistant professor, Perelman School of Medicine, University of Pennsylvania, discusses HPV vaccination for patients with HPV-related head and neck cancer.

In HPV-related cancers, there are predictable epitopes that can be targeted. There was a study that investigated a therapeutic vaccine that targeted E6 and E7. This study was able to show that immune responses were quite common in patients with head and neck cancer who received this HPV vaccine in the adjuvant setting.

There will be a study that combines this therapeutic vaccine with PD-1/PD-L1 inhibition, which is an exciting next step, according to Bauml. Since there are reliable epitopes in head and neck cancer, such as HPV and Epstein-Barr virus (EBV), this is a space where cellular therapies can be used. For example, cellular therapies such as T-cell receptor therapies or chimeric antigen receptor T-based therapies are options that Bauml hopes to explore in the future.
 


Joshua Bauml, MD, assistant professor, Perelman School of Medicine, University of Pennsylvania, discusses HPV vaccination for patients with HPV-related head and neck cancer.

In HPV-related cancers, there are predictable epitopes that can be targeted. There was a study that investigated a therapeutic vaccine that targeted E6 and E7. This study was able to show that immune responses were quite common in patients with head and neck cancer who received this HPV vaccine in the adjuvant setting.

There will be a study that combines this therapeutic vaccine with PD-1/PD-L1 inhibition, which is an exciting next step, according to Bauml. Since there are reliable epitopes in head and neck cancer, such as HPV and Epstein-Barr virus (EBV), this is a space where cellular therapies can be used. For example, cellular therapies such as T-cell receptor therapies or chimeric antigen receptor T-based therapies are options that Bauml hopes to explore in the future.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations Across Lung, Head and Neck, and Bladder CancersApr 28, 20182.0
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
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