Dr. Berlin on Potential Targets in Pancreatic Cancer

Jordan D. Berlin, MD
Published: Tuesday, Apr 02, 2019



Jordan D. Berlin, MD, Ingram Professor of Cancer Research, professor of medicine, VICC associate director for clinical research strategy, director, Phase I Program, gastrointestinal malignancies, clinical trials, Department of Medicine, Vanderbilt University Medical Center, discusses potential targets in pancreatic cancer.

Some patients have HER2 amplification, though a larger percentage of patients have DNA damage repair defects, says Berlin. It may be possible to target SMAD4, and in doing so gain insight into the tumor’s behavior. There are other targets with the same potential, says Berlin. Enrollment on Precision Promise trials look very promising in that regard. Next-generation sequencing should also be used to determine what a patient’s mutation profile is.

Additionally, every patient with pancreatic cancer needs genetic counseling, not just genetic testing, says Berlin. Genetic counselors, alongside medical oncologists, are crucial in the treatment of these patients. The optimal time for genetic counseling is at diagnosis. As such, the discussion about a genetic counseling referral should be part of the initial consultation.
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Jordan D. Berlin, MD, Ingram Professor of Cancer Research, professor of medicine, VICC associate director for clinical research strategy, director, Phase I Program, gastrointestinal malignancies, clinical trials, Department of Medicine, Vanderbilt University Medical Center, discusses potential targets in pancreatic cancer.

Some patients have HER2 amplification, though a larger percentage of patients have DNA damage repair defects, says Berlin. It may be possible to target SMAD4, and in doing so gain insight into the tumor’s behavior. There are other targets with the same potential, says Berlin. Enrollment on Precision Promise trials look very promising in that regard. Next-generation sequencing should also be used to determine what a patient’s mutation profile is.

Additionally, every patient with pancreatic cancer needs genetic counseling, not just genetic testing, says Berlin. Genetic counselors, alongside medical oncologists, are crucial in the treatment of these patients. The optimal time for genetic counseling is at diagnosis. As such, the discussion about a genetic counseling referral should be part of the initial consultation.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Navigating Treatment Decisions in Pancreatic Cancer: Key QuestionsJun 29, 20191.5
Community Practice Connections™: 2nd Annual International Congress on Oncology Pathology™Aug 31, 20191.5
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