Stay tuned for our LIVE OncLive News Network coverage straight from the #ASH18 conference floor! 

Dr. Blackwell on Margetuximab for HER2+ Breast Cancer

Kimberly L. Blackwell, MD
Published: Tuesday, Jan 19, 2016



Kimberly L. Blackwell, MD, professor of Medicine, assistant professor of Radiation Oncology, Duke Cancer Institute, discusses the mechanism of action for margetuximab (MGAH22-01) and discusses its potential as a treatment of patients with HER2-positive breast cancer.

The constant domain of margetuximab, a HER2-targeting monoclonal antibody engineered for increased Fc-domain binding, has been changed by five amino acids, Blackwell explains. The agent stimulates natural killer cells and tumor-associated macrophages more and inhibits the inhibitory immune cells less. This should offer more of a vigorous immune response against HER2.

Phase I/II data examining the efficacy of margetuximab was presented at the 2015 ASCO Annual Meeting. A phase III study is ongoing, she adds.



Kimberly L. Blackwell, MD, professor of Medicine, assistant professor of Radiation Oncology, Duke Cancer Institute, discusses the mechanism of action for margetuximab (MGAH22-01) and discusses its potential as a treatment of patients with HER2-positive breast cancer.

The constant domain of margetuximab, a HER2-targeting monoclonal antibody engineered for increased Fc-domain binding, has been changed by five amino acids, Blackwell explains. The agent stimulates natural killer cells and tumor-associated macrophages more and inhibits the inhibitory immune cells less. This should offer more of a vigorous immune response against HER2.

Phase I/II data examining the efficacy of margetuximab was presented at the 2015 ASCO Annual Meeting. A phase III study is ongoing, she adds.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Oncology Best Practice™ Decision Points in Advanced NSCLC: Assessing Treatment Options Beyond Disease ProgressionNov 30, 20181.0
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
Publication Bottom Border
Border Publication
x