Dr. Borchmann Discusses the Updated Analysis of JULIET in DLBCL

Peter Borchmann, MD
Published: Wednesday, Jun 20, 2018



Peter Borchmann, MD, professor, University Hospital of Cologne, Cologne, Germany, discusses the updated analysis of the JULIET trial in patients with diffuse large B-cell lymphoma (DLBCL).

Updated results from the phase II JULIET trial of the chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel (Kymriah) in patients with relapsed/refractory DLBCL were presented at the 2018 European Hematology Association Congress. At a median follow-up of 14.1 months, the objective response rate was 52%, which induced a complete response (CR) rate of 40% and a partial response (PR) rate of 12%. Borchmann says that these responses are very encouraging.

Many patients who achieve a PR went on to reach a CR about 9 to 12 months later, Borchmann notes. The 12-month relapse-free survival (RFS) rate in patients with a CR was 78.5% (95% CI, 60%-89%), and the 12-month RFS rate in all responders was 65% (95% CI, 49%-78%).

Additionally, Borchmann explains that the gene signature of the CAR T cell can be followed for up to 2 years, which can help investigators determine the ongoing efficacy of the single infusion.
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Peter Borchmann, MD, professor, University Hospital of Cologne, Cologne, Germany, discusses the updated analysis of the JULIET trial in patients with diffuse large B-cell lymphoma (DLBCL).

Updated results from the phase II JULIET trial of the chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel (Kymriah) in patients with relapsed/refractory DLBCL were presented at the 2018 European Hematology Association Congress. At a median follow-up of 14.1 months, the objective response rate was 52%, which induced a complete response (CR) rate of 40% and a partial response (PR) rate of 12%. Borchmann says that these responses are very encouraging.

Many patients who achieve a PR went on to reach a CR about 9 to 12 months later, Borchmann notes. The 12-month relapse-free survival (RFS) rate in patients with a CR was 78.5% (95% CI, 60%-89%), and the 12-month RFS rate in all responders was 65% (95% CI, 49%-78%).

Additionally, Borchmann explains that the gene signature of the CAR T cell can be followed for up to 2 years, which can help investigators determine the ongoing efficacy of the single infusion.

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