Dr. Dang on Neratinib in Patients With HER2-Positive Breast Cancer

Chau Dang, MD
Published: Thursday, Aug 11, 2016


Chau Dang, MD, medical oncologist, chief, West Harrison Medical Oncology Service, Memorial Sloan Kettering Cancer Center, discusses the potential of neratinib as part of a combination treatment for patients with HER2-positive breast cancer.

Currently, neratinib is being explored in combination with capecitabine versus lapatinib plus capecitabine in the phase III NALA study for HER2-positive patients who have received more than 2 treatments. This trial will allow researchers to determine whether this combination can be another treatment option for patients.

Dang explains that the incidence of grade 3 diarrhea associated with neratinib is an ongoing and significant issue; however, this toxicity can be managed through anti-diarrheal agents. Other small molecules are being developed in order to target these patients who also have brain metastases.
SELECTED
LANGUAGE

Chau Dang, MD, medical oncologist, chief, West Harrison Medical Oncology Service, Memorial Sloan Kettering Cancer Center, discusses the potential of neratinib as part of a combination treatment for patients with HER2-positive breast cancer.

Currently, neratinib is being explored in combination with capecitabine versus lapatinib plus capecitabine in the phase III NALA study for HER2-positive patients who have received more than 2 treatments. This trial will allow researchers to determine whether this combination can be another treatment option for patients.

Dang explains that the incidence of grade 3 diarrhea associated with neratinib is an ongoing and significant issue; however, this toxicity can be managed through anti-diarrheal agents. Other small molecules are being developed in order to target these patients who also have brain metastases.



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: How to Use Liquid Biopsies Throughout the Lung Cancer Treatment Continuum OnlineJan 31, 20191.5
Community Practice Connections™: Current Status and the Future Potential of CAR T-Cell Therapy for Lymphoid Malignancies: The Experts Weigh-In on Recent Data and Clinical ExperienceJan 31, 20192.0
Publication Bottom Border
Border Publication
x