Dr. Drilon on Immunotherapy in Lung Cancer

Alexander Drilon, MD
Published: Tuesday, Mar 28, 2017



Alexander Drilon, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses immunotherapy in patients with lung cancer.

Not every patient is going to benefit from immunotherapy, explains Drilon. Data have recently been discovered that the likelihood of response to single-agent immune checkpoint inhibitors in EGFR-mutant and ALK-rearranged lung cancers is relatively low.

These low response rates could be because the tumors that harbor a driver may be more naïve and possibly less visible to the immune system, states Drilon. In clinical trials, the same level of response is not being seen in the patients who have a more substantial smoking history and who don’t have EGFR, ALK, or high PD-L1 staining.
 


Alexander Drilon, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses immunotherapy in patients with lung cancer.

Not every patient is going to benefit from immunotherapy, explains Drilon. Data have recently been discovered that the likelihood of response to single-agent immune checkpoint inhibitors in EGFR-mutant and ALK-rearranged lung cancers is relatively low.

These low response rates could be because the tumors that harbor a driver may be more naïve and possibly less visible to the immune system, states Drilon. In clinical trials, the same level of response is not being seen in the patients who have a more substantial smoking history and who don’t have EGFR, ALK, or high PD-L1 staining.
 



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: ALK-Positive NSCLC: Emerging Strategies to Inform Sequencing, Optimize Outcomes, and Address Unmet Clinical Needs Along the Disease ContinuumAug 29, 20181.5
Community Practice Connections™: Oncogenic Tumor Board in Advanced NSCLC: Leveraging Actionable Mutations Along the Disease Continuum to Optimize Patient OutcomesAug 30, 20182.0
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