Dr. Drilon on NTRK Rearrangement in Lung Cancer

Alexander Drilon, MD
Published: Thursday, Mar 02, 2017



Alexander Drilon, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses NTRK rearrangement in patients with lung cancer.

NTRK rearrangements are recurrent gene fusions that are found in a rare minority of patients with lung cancer, explains Drilon. However, looking across other solid tumors, they can be found in head and neck cancer, sarcomas, and breast cancer.

According to Drilon, the interesting thing about TRK fusions, is that they are very actionable in terms of targeted therapy. There are 2 different targeted agents, entrectinib and LOXO-101, that are in phase II testing for any patients who have solid tumors with NTRK rearrangement. Both drugs have achieved dramatic responses, regardless of histology in earlier phase I studies.
 


Alexander Drilon, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses NTRK rearrangement in patients with lung cancer.

NTRK rearrangements are recurrent gene fusions that are found in a rare minority of patients with lung cancer, explains Drilon. However, looking across other solid tumors, they can be found in head and neck cancer, sarcomas, and breast cancer.

According to Drilon, the interesting thing about TRK fusions, is that they are very actionable in terms of targeted therapy. There are 2 different targeted agents, entrectinib and LOXO-101, that are in phase II testing for any patients who have solid tumors with NTRK rearrangement. Both drugs have achieved dramatic responses, regardless of histology in earlier phase I studies.
 



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TitleExpiration DateCME Credits
Community Practice Connections™: Working Group to Optimize Outcomes in EGFR-mutated Lung Cancers: Evolving Concepts for Nurses to Facilitate and Improve Patient CareJun 30, 20181.5
Community Practice Connections™: 4th Annual Miami Lung Cancer Conference®Jun 30, 20187.0
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