Dr. Ellis on Abemaciclib in HR-Positive Breast Cancer

Matthew J. Ellis, MD, PhD
Published: Tuesday, Jul 31, 2018



Matthew J. Ellis, MD, PhD, professor and director, Lester and Sue Smith Breast Center, associate director of precision medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, discusses the use of abemaciclib (Verzenio) in hormone receptor-positive breast cancer.

Following the frontline approval of abemaciclib, Ellis’s interest lies in its potential use as a later-line therapy in patients who have not had an opportunity to be treated with a CDK4/6 inhibitor. Because of that approval, Ellis says that he may favor its use in patients with multiple resistance to multiple endocrine agents. These patients would have already had fulvestrant alone or fulvestrant and an aromatase inhibitor (AI).

Preclinical data with ESR1 mutations and ESR1 fusions indicate that downstream inhibition is very effective with CDK4/6 even when the estrogen receptor is mutationally interrupted, states Ellis. Some of these diagnoses are also being made with liquid biopsy analysis. The presence of an ESR1 mutation and prior AI therapy with fulvestrant might be a situation where in it is logical to consider abemaciclib as third-line monotherapy.


Matthew J. Ellis, MD, PhD, professor and director, Lester and Sue Smith Breast Center, associate director of precision medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, discusses the use of abemaciclib (Verzenio) in hormone receptor-positive breast cancer.

Following the frontline approval of abemaciclib, Ellis’s interest lies in its potential use as a later-line therapy in patients who have not had an opportunity to be treated with a CDK4/6 inhibitor. Because of that approval, Ellis says that he may favor its use in patients with multiple resistance to multiple endocrine agents. These patients would have already had fulvestrant alone or fulvestrant and an aromatase inhibitor (AI).

Preclinical data with ESR1 mutations and ESR1 fusions indicate that downstream inhibition is very effective with CDK4/6 even when the estrogen receptor is mutationally interrupted, states Ellis. Some of these diagnoses are also being made with liquid biopsy analysis. The presence of an ESR1 mutation and prior AI therapy with fulvestrant might be a situation where in it is logical to consider abemaciclib as third-line monotherapy.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
Community Practice Connections™: 1st Annual International Congress of Oncology Pathology™: Towards Harmonization of Pathology and Oncology StandardsAug 30, 20182.0
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