Dr. Frakes on Late Toxicities in HPV-Associated Oropharynx Squamous Cell Carcinoma

Jessica Frakes, MD
Published: Friday, Sep 16, 2016



Jessica Frakes, MD, assistant member, Department of Radiation Oncology, Moffitt Cancer Center, discusses some of the late toxicities seen in patients with HPV-positive oropharynx squamous cell carcinoma.

The most common toxicity reported in the current study was the requirement of a feeding tube. According to Frakes, patients at Moffitt Cancer Center are not prophylactically given feeding tubes, unless they have had significant weight loss pre-treatment.

Six patients had soft tissue necrosis of the skin or jaw, though 4 of those 6 patients had resolution once they received hyperbaric oxygen therapy. Generally speaking, researchers are very aggressive when it comes to managing these late toxicities, says Frakes.


Jessica Frakes, MD, assistant member, Department of Radiation Oncology, Moffitt Cancer Center, discusses some of the late toxicities seen in patients with HPV-positive oropharynx squamous cell carcinoma.

The most common toxicity reported in the current study was the requirement of a feeding tube. According to Frakes, patients at Moffitt Cancer Center are not prophylactically given feeding tubes, unless they have had significant weight loss pre-treatment.

Six patients had soft tissue necrosis of the skin or jaw, though 4 of those 6 patients had resolution once they received hyperbaric oxygen therapy. Generally speaking, researchers are very aggressive when it comes to managing these late toxicities, says Frakes.

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Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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