Dr. Francesco Forconi on B-cell Receptor Structure and Function in CLL

Francesco Forconi, MD
Published: Wednesday, Jul 06, 2016

 
Francesco Forconi, MD, associate professor of Hematology, University of Southampton, United Kingdom, discusses the role of the B-cell receptor (BCR) in chronic lymphocytic leukemia (CLL).
 
CLL is a disease with a very variable outcome, says Forconi.  It was recently published that the ability of CLL to progress depends on the BCR immunoglobulin (IgM) levels and the BCR signaling levels. Those cells that have a stronger capacity through IgM will progress more rapidly than those that have low IgM signaling capacity or lower IgM levels.  
 
By targeting this molecule it may be possible to improve outcomes, says Forconi. A better understanding of how the BCR functions in CLL will make it easier to design a therapeutic regimen to fight the disease, he says.
SELECTED
LANGUAGE
 
Francesco Forconi, MD, associate professor of Hematology, University of Southampton, United Kingdom, discusses the role of the B-cell receptor (BCR) in chronic lymphocytic leukemia (CLL).
 
CLL is a disease with a very variable outcome, says Forconi.  It was recently published that the ability of CLL to progress depends on the BCR immunoglobulin (IgM) levels and the BCR signaling levels. Those cells that have a stronger capacity through IgM will progress more rapidly than those that have low IgM signaling capacity or lower IgM levels.  
 
By targeting this molecule it may be possible to improve outcomes, says Forconi. A better understanding of how the BCR functions in CLL will make it easier to design a therapeutic regimen to fight the disease, he says.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Atlanta: Advances in the Treatment of Chronic Lymphocytic LeukemiaFeb 28, 20190.5
Community Practice Connections™: 2nd Annual International Congress on Immunotherapies in Cancer™: Focus on Practice-Changing ApplicationFeb 28, 20192.0
Publication Bottom Border
Border Publication
x