Dr. Goy on the Approval of Pembrolizumab in PMBCL

Andre Goy, MD
Published: Wednesday, Jun 13, 2018



Andre Goy, MD, chairman and director, chief of Lymphoma, and director of Clinical and Translational Cancer Research at John Theurer Cancer Center, discusses the FDA approval of pembrolizumab (Keytruda) for patients with relapsed/refractory primary mediastinal large B-cell lymphoma (PMBCL).

The approval was based on findings from a cohort of the phase II KEYNOTE-170, trial evaluating the anti–PD-1 agent in 29 patients with PMBCL. The trial is an ongoing, non-randomized, international, 2-cohort, multicenter study investigating pembrolizumab every 3 weeks in patients who relapsed after, were refractory to, or were ineligible for autologous stem cell transplant and failed 2 or more prior lines of therapy, and in patients with relapsed or refractory Richter syndrome.


Andre Goy, MD, chairman and director, chief of Lymphoma, and director of Clinical and Translational Cancer Research at John Theurer Cancer Center, discusses the FDA approval of pembrolizumab (Keytruda) for patients with relapsed/refractory primary mediastinal large B-cell lymphoma (PMBCL).

The approval was based on findings from a cohort of the phase II KEYNOTE-170, trial evaluating the anti–PD-1 agent in 29 patients with PMBCL. The trial is an ongoing, non-randomized, international, 2-cohort, multicenter study investigating pembrolizumab every 3 weeks in patients who relapsed after, were refractory to, or were ineligible for autologous stem cell transplant and failed 2 or more prior lines of therapy, and in patients with relapsed or refractory Richter syndrome.

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