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Dr. Gregory Riely on Using Next-Generation Sequencing to Identify Lung Cancer Mutations

Gregory Riely, MD
Published: Thursday, Dec 03, 2015



Gregory Riely, MD, Medical Oncologist, Vice Chair, Clinical Trials Office, Department of Medicine, Memorial Sloan Kettering, discusses the benefits and challenges of using next-generation sequencing to identify mutations in lung cancer.

With so many mutations now identified in lung cancer, including EGFR, KRAS, BRAF, ALK, and ROS1, it can be difficult to have enough tissue available to test for all of them, says Riely. This means that key tests are not able to be done using standard testing methods.

Next-generation sequencing allows hundreds of genes to be tested for using a very small biopsy specimen.

However, the large volume or results next-generations sequencing provides, can be challenging to understand and utilize, says Riely. Pathologists and oncologists should focus their efforts on only the most common or well-understood mutations in order to make next-generation sequencing an effective tool, he adds.



Gregory Riely, MD, Medical Oncologist, Vice Chair, Clinical Trials Office, Department of Medicine, Memorial Sloan Kettering, discusses the benefits and challenges of using next-generation sequencing to identify mutations in lung cancer.

With so many mutations now identified in lung cancer, including EGFR, KRAS, BRAF, ALK, and ROS1, it can be difficult to have enough tissue available to test for all of them, says Riely. This means that key tests are not able to be done using standard testing methods.

Next-generation sequencing allows hundreds of genes to be tested for using a very small biopsy specimen.

However, the large volume or results next-generations sequencing provides, can be challenging to understand and utilize, says Riely. Pathologists and oncologists should focus their efforts on only the most common or well-understood mutations in order to make next-generation sequencing an effective tool, he adds.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Oncology Briefings™: Updates in Novel Therapeutic Options for Lung Neuroendocrine TumorsMay 31, 20181.0
Community Practice Connections™: Working Group to Optimize Outcomes in EGFR-mutated Lung Cancers: Evolving Concepts for Nurses to Facilitate and Improve Patient CareJun 30, 20181.5
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