Dr. Grignani on the Role of Trabectedin in Sarcoma

Giovanni Grignani, MD
Published: Friday, Feb 03, 2017



Giovanni Grignani, MD, medical oncologist, Candiolo Cancer Institute IRCCS, discusses some of the data seen thus far with trabectedin (Yondelis) as a treatment for patients with sarcoma.

In a phase II study involving patients with metastatic or locally relapsed uterine leiomyosarcoma (MLRUL) pretreated with conventional chemotherapy, trabectedin met the study criteria, with a 6-month progression-free survival (PFS) rate of 33% and a 12-month PFS rate of 20%.

According to Grignani, trabectedin is just one of the many innovative options that oncologists have when dealing with the increasing percentage of patients with this disease. Moreover, he says this patient population is aging, and physicians frequently find elderly patients who have several comorbidities, which can disrupt an otherwise efficacious course of treatment.



Giovanni Grignani, MD, medical oncologist, Candiolo Cancer Institute IRCCS, discusses some of the data seen thus far with trabectedin (Yondelis) as a treatment for patients with sarcoma.

In a phase II study involving patients with metastatic or locally relapsed uterine leiomyosarcoma (MLRUL) pretreated with conventional chemotherapy, trabectedin met the study criteria, with a 6-month progression-free survival (PFS) rate of 33% and a 12-month PFS rate of 20%.

According to Grignani, trabectedin is just one of the many innovative options that oncologists have when dealing with the increasing percentage of patients with this disease. Moreover, he says this patient population is aging, and physicians frequently find elderly patients who have several comorbidities, which can disrupt an otherwise efficacious course of treatment.


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Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Moving Forward From the Status Quo for the Treatment of Soft Tissue Sarcoma: Key Questions and New Answers to Optimize OutcomesOct 31, 20182.0
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