Dr. Hamlin on the Significance of the ZUMA-I Trial

Paul A. Hamlin, MD
Published: Monday, Mar 26, 2018



Paul A. Hamlin, MD, chief, Basking Ridge Medical Oncology Service, Memorial Sloan Kettering Cancer Center, discusses the importance of the ZUMA-I trial results in the field of B-cell lymphoma.

One of the big stories in diffuse large B-cell lymphoma that came out of the 2017 ASH Annual Meeting was the use of CAR T cells. CAR T-cell therapy have been shown to be active in patients with relapsed large cell lymphoma and induce meaningful response rates.

Updated data from the 2017 ASH Annual Meeting showed that patients can achieve durable remissions. This follow-up data, now approaching 1.5 years, is an important landmark in large cell lymphoma. Typically, the first 18 months are when events happen, especially in the upfront setting. In the relapsed setting, it’s even sooner. In the trial, about 30% to 40% of patients who responded to CAR T-cell therapy have maintained their response.
 
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Paul A. Hamlin, MD, chief, Basking Ridge Medical Oncology Service, Memorial Sloan Kettering Cancer Center, discusses the importance of the ZUMA-I trial results in the field of B-cell lymphoma.

One of the big stories in diffuse large B-cell lymphoma that came out of the 2017 ASH Annual Meeting was the use of CAR T cells. CAR T-cell therapy have been shown to be active in patients with relapsed large cell lymphoma and induce meaningful response rates.

Updated data from the 2017 ASH Annual Meeting showed that patients can achieve durable remissions. This follow-up data, now approaching 1.5 years, is an important landmark in large cell lymphoma. Typically, the first 18 months are when events happen, especially in the upfront setting. In the relapsed setting, it’s even sooner. In the trial, about 30% to 40% of patients who responded to CAR T-cell therapy have maintained their response.
 



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Online CME Activities
TitleExpiration DateCME Credits
Archived Version of a Live Webcast: Virtual Current Trends™: European Perspectives on the Advancing Role of CAR T-Cell Therapy in Hematologic MalignanciesJun 29, 20192.0
Community Practice Connections™: Practical Application of Sequencing for EGFR-Mutant Lung Cancers: A Focus on Recent Evidence and Key Next Steps in TrialsJun 29, 20192.5
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