Dr. Hofmeister on Reolysin Combined With Carfilzomib for Multiple Myeloma
Craig Hofmeister, MD, assistant professor of Internal Medicine, Division of Hematology, Department of Internal Medicine, Ohio State University, discusses a study that examined the efficacy of reolysin combined with carfilzomib in patients with relapsed multiple myeloma.
Craig Hofmeister, MD, assistant professor of Internal Medicine, Division of Hematology, Department of Internal Medicine, Ohio State University, discusses a study that examined the efficacy of reolysin combined with carfilzomib in patients with relapsed multiple myeloma.
This phase I dose-escalation study examined the relapsed population, as well as some patients who were refractory to carfilzomib, Hofmeister explains. A total of 12 patients received the combination of reolysin, an oncolytic virus, and carfilzomib at two different levels.
At the starting dose level, all patients responded to the regimen; 6 patients were able to remain on therapy without disease progression. At a decreased dose, the majority of patients did not respond to the combination, which was an unexpected result, Hofmeister says.
