Stay tuned for our LIVE OncLive News Network coverage straight from the #ASH18 conference floor! 

Dr. Kaplan on the Treatment of Pediatric Patients With Sarcoma

Rosandra N. Kaplan, MD
Published: Friday, Aug 17, 2018



Rosandra N. Kaplan, MD, investigator, Pediatric Oncology Branch, Head, Tumor Microenvironment Section, National Cancer Institute, discusses the treatment of pediatric patients with sarcoma.

There is very good upfront therapy available for pediatric patients with osteosarcoma, Ewing sarcoma, and rhabdoid myosarcoma, Kaplan says. Multimodality chemotherapy—often with radiation and surgery—is the standard of care for these patients, and the majority will respond and do well. Kaplan says that there remains a subset of patients who do not respond and have recurrent or metastatic disease.

The options for the treatment of pediatric patients with recurrent or metastatic sarcoma are limited. Overall, the patients are healthy because they are young and fit, but they continue to fail on the limited therapies that are available and grow more resistant to chemotherapy as time goes on. Kaplan says that if resistance is better understood in both the tumor cell and the microenvironment, therapies can be used more effectively.


Rosandra N. Kaplan, MD, investigator, Pediatric Oncology Branch, Head, Tumor Microenvironment Section, National Cancer Institute, discusses the treatment of pediatric patients with sarcoma.

There is very good upfront therapy available for pediatric patients with osteosarcoma, Ewing sarcoma, and rhabdoid myosarcoma, Kaplan says. Multimodality chemotherapy—often with radiation and surgery—is the standard of care for these patients, and the majority will respond and do well. Kaplan says that there remains a subset of patients who do not respond and have recurrent or metastatic disease.

The options for the treatment of pediatric patients with recurrent or metastatic sarcoma are limited. Overall, the patients are healthy because they are young and fit, but they continue to fail on the limited therapies that are available and grow more resistant to chemotherapy as time goes on. Kaplan says that if resistance is better understood in both the tumor cell and the microenvironment, therapies can be used more effectively.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Oncology Best Practice™ Decision Points in Advanced NSCLC: Assessing Treatment Options Beyond Disease ProgressionNov 30, 20181.0
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
Publication Bottom Border
Border Publication
x