Dr. Kwa on the TAILORx Trial in Breast Cancer

Name: Dr. Kwa on the TAILORx Trial in Breast Cancer
Uploaded: 2018-07-05T22:30:00.000Z
Description: Maryann J. Kwa, MD, instructor, Department of Medicine, NYU Langone’s Perlmutter Cancer Center, discusses the results of the TAILORx trial in breast cancer.

July 5, 2018

Maryann J. Kwa, MD

Video

Maryann J. Kwa, MD, instructor, Department of Medicine, NYU Langone’s Perlmutter Cancer Center, discusses the results of the TAILORx trial in breast cancer.

Findings from the phase III TAILORx trial were presented at the 2018 ASCO Annual Meeting. The study examined intermediate-risk patients with hormone receptor-positive, HER2-negative, node-negative, early-stage breast cancer based on the 21-gene recurrence score. These were patients who had an Oncotype DX Breast Recurrence Score test of 16 to 25. Half of patients were randomized to receive chemotherapy and endocrine therapy and half were randomized to receive endocrine therapy alone. The study found that there was no difference in disease-free survival between groups, said Kwa.

The noninferiority of endocrine therapy alone compared with endocrine therapy and chemotherapy (HR, 1.08; 95% CI, 0.94-1.24; P = .26) met the trial’s primary endpoint.

However, Kwa notes that a subgroup analysis that looked at women who were 58 years of age or younger found a small benefit with chemotherapy and endocrine therapy.