Dr. Linehan on Gene Mutations in Papillary Kidney Cancer

W. Marston Linehan, MD
Published: Thursday, Mar 09, 2017



W. Marston Linehan, MD, chief, Urologic Oncology Branch, National Cancer Institute, discusses gene mutations in papillary kidney cancer.

Hereditary papillary renal carcinoma (HPRC) is a hereditary kidney cancer that is studied to help better understand non-hereditary kidney cancer. The patients with HRPC who have a germline MET-gene mutation are highly likely to develop bilateral, multifocal, type 1 papillary kidney cancer.

The MET-gene is mutated in a significant number of these patients, explains Linehan. The gene is altered in over 80% of tumors from patients with type 1 papillary kidney cancer.
 
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W. Marston Linehan, MD, chief, Urologic Oncology Branch, National Cancer Institute, discusses gene mutations in papillary kidney cancer.

Hereditary papillary renal carcinoma (HPRC) is a hereditary kidney cancer that is studied to help better understand non-hereditary kidney cancer. The patients with HRPC who have a germline MET-gene mutation are highly likely to develop bilateral, multifocal, type 1 papillary kidney cancer.

The MET-gene is mutated in a significant number of these patients, explains Linehan. The gene is altered in over 80% of tumors from patients with type 1 papillary kidney cancer.
 

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