Dr. LoRusso on PARP Inhibitors in Triple-Negative Breast Cancer

Patricia LoRusso, DO
Published: Thursday, Sep 29, 2016



Patricia LoRusso, DO, professor of Medicine (Medical Oncology), associate director, Innovative Medicine, Yale Cancer Center, discusses the role of PARP inhibitors in triple negative breast cancer (TNBC).

PARP inhibitors are extremely important in BRCA-mutant disease, explains LoRusso. Studies evaluating their role in ovarian cancer have shown that PARP inhibitors can significantly increase the effectiveness of targeted agents.

Prior chemotherapy exposure, even in the adjuvant setting, can actually hinder the efficacy of PARP inhibitors by altering the BRCA mutation and thus restoring the tumor's ability to undergo homologous recombination and repair, says LoRusso.


Patricia LoRusso, DO, professor of Medicine (Medical Oncology), associate director, Innovative Medicine, Yale Cancer Center, discusses the role of PARP inhibitors in triple negative breast cancer (TNBC).

PARP inhibitors are extremely important in BRCA-mutant disease, explains LoRusso. Studies evaluating their role in ovarian cancer have shown that PARP inhibitors can significantly increase the effectiveness of targeted agents.

Prior chemotherapy exposure, even in the adjuvant setting, can actually hinder the efficacy of PARP inhibitors by altering the BRCA mutation and thus restoring the tumor's ability to undergo homologous recombination and repair, says LoRusso.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Chicago: Advances in the Treatment of Breast CancerJul 31, 20181.0
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
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