Dr. Luke on Immunotherapy Diagnostics in Melanoma

Jason Luke, MD
Published: Thursday, Oct 20, 2016



Jason Luke, MD, assistant professor of Medicine, The University of Chicago Medicine, discusses the various methods involved in immunotherapy diagnostics in the treatment landscape of melanoma.

One such method is PD-L1 immunohistochemistry. However, Luke notes, even patients who are technically negative for PD-L1 expression have been found to benefit more from these types of drugs than other agents.

Another method involves looking at the mutational load in the cancer. Some oncologists have found that, if tumors have a very high mutational rate in the cancer, the likelihood of response is very high, explains Luke.


Jason Luke, MD, assistant professor of Medicine, The University of Chicago Medicine, discusses the various methods involved in immunotherapy diagnostics in the treatment landscape of melanoma.

One such method is PD-L1 immunohistochemistry. However, Luke notes, even patients who are technically negative for PD-L1 expression have been found to benefit more from these types of drugs than other agents.

Another method involves looking at the mutational load in the cancer. Some oncologists have found that, if tumors have a very high mutational rate in the cancer, the likelihood of response is very high, explains Luke.



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Evolving Roles for Targeted Melanoma Therapies: Assessing Rapid Progress in the Field and Looking Toward Future CombinationsFeb 28, 20191.5
Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of ImmunotherapyAug 13, 20191.5
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