Stay tuned for our LIVE OncLive News Network coverage straight from the #ASH18 conference floor! 

Dr. Marshall on Single-Agent and Combination Immunotherapy Applications in MSI-H mCRC

John L. Marshall, MD
Published: Wednesday, Feb 14, 2018



John L. Marshall, MD, chief, Division of Hematology/Oncology, Medstar Georgetown University Hospital director, Otto J. Ruesch Center for the Cure of Gastrointestinal Cancer, Georgetown-Lombardi Comprehensive Cancer Center, discusses the progression of immunotherapy in colon cancer.

Immunotherapy was once believed to have no impact on colon cancers. Since then, researchers have looked at immunotherapy in microsatellite instability-high (MSI-H) colon cancers, or mismatch repair deficient colon cancers. Results showed that checkpoint inhibitors work very well in that subgroup.

The FDA has since approved 2 checkpoint inhibitors as single agents in refractory metastatic colon cancers if they are MSI-H. Physicians know from melanoma and other cancers that combining immunotherapies can result in even greater benefit. The most recent study compared nivolumab (Opdivo) plus ipilimumab (Yervoy) in MSI-H colon cancers.  Although physicians saw more toxicity and cost, there was a higher benefit rate, further increasing the number of patients who are benefiting from immunotherapy.
 


John L. Marshall, MD, chief, Division of Hematology/Oncology, Medstar Georgetown University Hospital director, Otto J. Ruesch Center for the Cure of Gastrointestinal Cancer, Georgetown-Lombardi Comprehensive Cancer Center, discusses the progression of immunotherapy in colon cancer.

Immunotherapy was once believed to have no impact on colon cancers. Since then, researchers have looked at immunotherapy in microsatellite instability-high (MSI-H) colon cancers, or mismatch repair deficient colon cancers. Results showed that checkpoint inhibitors work very well in that subgroup.

The FDA has since approved 2 checkpoint inhibitors as single agents in refractory metastatic colon cancers if they are MSI-H. Physicians know from melanoma and other cancers that combining immunotherapies can result in even greater benefit. The most recent study compared nivolumab (Opdivo) plus ipilimumab (Yervoy) in MSI-H colon cancers.  Although physicians saw more toxicity and cost, there was a higher benefit rate, further increasing the number of patients who are benefiting from immunotherapy.
 



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Oncology Best Practice™ Decision Points in Advanced NSCLC: Assessing Treatment Options Beyond Disease ProgressionNov 30, 20181.0
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
Publication Bottom Border
Border Publication
x