Dr. Offin on Targeted Agents in MET- and RET-Altered NSCLC

Video

In Partnership With:

Michael D. Offin, MD, discusses targeted agents in MET- and RET-altered non–small cell lung cancer.

Michael D. Offin, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses targeted agents in MET- and RET-altered non—small cell lung cancer (NSCLC).

The current standard of care in MET-altered NSCLC is crizotinib (Xalkori), as outlined in the National Comprehensive Cancer Network (NCCN) guidelines. However, capmatinib, tepotinib, and savolitinib are all emerging agents in this space. Each agent had a slightly different safety profile with overall response rates (ORRs) ranging from 40% to 60%, according to data presented at the 2019 ASCO Annual Meeting.

In the RET space, the NCCN-recommended agents are somewhat toxic with suboptimal response rates, says Offin. Encouragingly, selpercatinib (formerly LOXO-292) and BLU-667 have shown greater tolerability. Although selpercatinib has shown a slightly higher ORR, both agents have been granted breakthrough therapy designations by the FDA for use in patients with RET fusion—positive NSCLC after progression on platinum-based chemotherapy.

Related Videos
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,
Guenther Koehne, MD, PhD
Alessandro Villa, DDS, PhD, MPH
Joseph Mikhael, MD
Michael Richardson, MD
Minesh Mehta, MD
Ruben Olivares, MD
Phillip J. Koo, MD