Dr. O'Neil Discusses the Current Treatment of Patients With CRC

Bert O'Neil, MD
Published: Wednesday, Mar 28, 2018



Bert O’Neil, MD, the Joseph W. and Jackie J. Cusick Professor of Oncology, professor of medicine, and director of the Phase I and Gastrointestinal Oncology Programs at Indiana University, discusses the current treatment of patients with colorectal cancer (CRC).

Currently, the average patient with CRC does well on chemotherapy and either a VEGF-targeted agent or an EGFR antibody, says O’Neil. The population that will definitely see a change in treatment is microsatellite instability-high, where immunotherapy may be a factor in the near future. Those studies have yet to read out.

O’Neil says that it is also early days in understanding the role of HER2 expression. Additionally, O’Neil asks whether early intervention is better in patients with BRAF mutations. Specific treatments for that population should be considered, he adds.
SELECTED
LANGUAGE


Bert O’Neil, MD, the Joseph W. and Jackie J. Cusick Professor of Oncology, professor of medicine, and director of the Phase I and Gastrointestinal Oncology Programs at Indiana University, discusses the current treatment of patients with colorectal cancer (CRC).

Currently, the average patient with CRC does well on chemotherapy and either a VEGF-targeted agent or an EGFR antibody, says O’Neil. The population that will definitely see a change in treatment is microsatellite instability-high, where immunotherapy may be a factor in the near future. Those studies have yet to read out.

O’Neil says that it is also early days in understanding the role of HER2 expression. Additionally, O’Neil asks whether early intervention is better in patients with BRAF mutations. Specific treatments for that population should be considered, he adds.



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Addressing Post-Transplant Obstacles: Current and Emerging Strategies to Evolve the Standard of Care for Patients With Graft-Versus-Host DiseaseMar 28, 20192.0
2017 Year in Review™: Clinical Impact of Immunotherapies in the Treatment of CancerMar 30, 20191.75
Publication Bottom Border
Border Publication
x