Dr. Osborne Discusses Targeting the HER2 Pathway in Breast Cancer

C. Kent Osborne, MD
Published: Monday, Apr 17, 2017



C. Kent Osborne, MD, director, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, discusses targeting the HER2 pathway in breast cancer.

Osborne says that chemotherapy may be avoidable by blocking the HER2 pathway with targeted therapies. Along with his collegues, Osborne hypothesizes that it would be more effective to use more targeted agents to block the pathway, as trastuzumab (Herceptin) cannot block all of the receptors alone.

Studies were then done using dual HER2-targeted therapies without chemotherapy with pathologic complete remission rates ranging between 20% and 40%, suggesting that some patients with HER2 overexpressing tumors may not need to undergo chemotherapy at all.
 


C. Kent Osborne, MD, director, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, discusses targeting the HER2 pathway in breast cancer.

Osborne says that chemotherapy may be avoidable by blocking the HER2 pathway with targeted therapies. Along with his collegues, Osborne hypothesizes that it would be more effective to use more targeted agents to block the pathway, as trastuzumab (Herceptin) cannot block all of the receptors alone.

Studies were then done using dual HER2-targeted therapies without chemotherapy with pathologic complete remission rates ranging between 20% and 40%, suggesting that some patients with HER2 overexpressing tumors may not need to undergo chemotherapy at all.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Chicago: Advances in the Treatment of Breast CancerJul 31, 20181.0
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
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