Dr. Patel on Emerging Therapeutic Strategies in MCL

Krish Patel, MD
Published: Wednesday, Mar 20, 2019



Krish Patel, MD, medical oncologist, Swedish Cancer Institute, discusses emerging therapeutic strategies and ongoing research in mantle cell lymphoma (MCL).

Research with chimeric antigen receptor (CAR) T-cell therapy is still preliminary in MCL, but it will be interesting to see how the modality impacts the paradigm, explains Patel. As in other lymphomas, there is a lot of excitement about this approach, but in MCL, it is too early to understand what the role of that therapy will be.

Additionally, there is a lot of excitement surrounding readouts of the some of the combination studies that are now being done with BCL-2 inhibitors, adds Patel. For example, combinations of BTK inhibitors and BCL-2 inhibitors, such as ibrutinib (Imbruvica) and venetoclax (Venclexta). Those studies are being designed slightly differently than historical studies with a fixed duration of therapy. It will be insightful to see how different classes of therapy with potentially different toxicity profiles fare when combined with a BCL-2 inhibitor like venetoclax, concludes Patel.
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Krish Patel, MD, medical oncologist, Swedish Cancer Institute, discusses emerging therapeutic strategies and ongoing research in mantle cell lymphoma (MCL).

Research with chimeric antigen receptor (CAR) T-cell therapy is still preliminary in MCL, but it will be interesting to see how the modality impacts the paradigm, explains Patel. As in other lymphomas, there is a lot of excitement about this approach, but in MCL, it is too early to understand what the role of that therapy will be.

Additionally, there is a lot of excitement surrounding readouts of the some of the combination studies that are now being done with BCL-2 inhibitors, adds Patel. For example, combinations of BTK inhibitors and BCL-2 inhibitors, such as ibrutinib (Imbruvica) and venetoclax (Venclexta). Those studies are being designed slightly differently than historical studies with a fixed duration of therapy. It will be insightful to see how different classes of therapy with potentially different toxicity profiles fare when combined with a BCL-2 inhibitor like venetoclax, concludes Patel.

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