Dr. Patnaik on Activity of SL-401 in Chronic Myelomonocytic Leukemia

Mrinal Patnaik, MBBS
Published: Friday, Dec 30, 2016



Mrinal Patnaik, MBBS, hematologist, Mayo Clinic, discusses the encouraging results seen in a phase II trial evaluating the activity of SL-401 in patients with advanced, high-risk myeloproliferative neoplasms (MPN), including chronic myelomonocytic leukemia (CMML).

SL-401 is a novel targeted therapy directed to the interleukin-3 receptor (CD123), a target overexpressed by many hematologic malignancies. CD123 has been shown to be expressed on MPN cells as well as microenvironmental immune cells, specifically plasmacytoid dendritic cells (pDCs), in the bone marrows of some patients with MPN including CMML.

Initial dosing of SL-401 appears to be well tolerated thus far in patients with MPN and CMML, with no unexpected toxicities observed.

The hope, says Patnaik, is that these researchers can improve patients' blood counts, reduce transfusion dependency, improve symptoms, and also produce improvement in terms of both overall and complete responses.


Mrinal Patnaik, MBBS, hematologist, Mayo Clinic, discusses the encouraging results seen in a phase II trial evaluating the activity of SL-401 in patients with advanced, high-risk myeloproliferative neoplasms (MPN), including chronic myelomonocytic leukemia (CMML).

SL-401 is a novel targeted therapy directed to the interleukin-3 receptor (CD123), a target overexpressed by many hematologic malignancies. CD123 has been shown to be expressed on MPN cells as well as microenvironmental immune cells, specifically plasmacytoid dendritic cells (pDCs), in the bone marrows of some patients with MPN including CMML.

Initial dosing of SL-401 appears to be well tolerated thus far in patients with MPN and CMML, with no unexpected toxicities observed.

The hope, says Patnaik, is that these researchers can improve patients' blood counts, reduce transfusion dependency, improve symptoms, and also produce improvement in terms of both overall and complete responses.



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
Medical Crossfire®: Clinical Updates on PARP Inhibition and its Evolving Use in the Treatment of CancersMay 30, 20181.5
Publication Bottom Border
Border Publication
x