Dr. Rogers Discusses Obinutuzumab, Ibrutinib, and Venetoclax Combination in CLL

Kerry Rogers, MD
Published: Friday, Dec 22, 2017



Kerry Rogers, MD, assistant professor, Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, discusses the initial results of the phase II treatment-naïve cohort in a phase Ib/II study of obinutuzumab (Gazyva), ibrutinib (Imbruvica), and venetoclax (Venclexta) in chronic lymphocytic leukemia (CLL).

This study investigates a chemotherapy-free combination, explains Rogers. Traditionally, there has been success with chemotherapy combination treatments. However, side effects of chemotherapy are difficult for many patients.

According to Rogers, these 3 agents have different mechanisms of action and non-overlapping toxicity profiles, making them an interesting combination to study.
 
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Kerry Rogers, MD, assistant professor, Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, discusses the initial results of the phase II treatment-naïve cohort in a phase Ib/II study of obinutuzumab (Gazyva), ibrutinib (Imbruvica), and venetoclax (Venclexta) in chronic lymphocytic leukemia (CLL).

This study investigates a chemotherapy-free combination, explains Rogers. Traditionally, there has been success with chemotherapy combination treatments. However, side effects of chemotherapy are difficult for many patients.

According to Rogers, these 3 agents have different mechanisms of action and non-overlapping toxicity profiles, making them an interesting combination to study.
 



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