Dr. Semrad on SPIDER Program to Understand Resistance to Therapies

Thomas J. Semrad, MD
Published: Monday, Oct 05, 2015



Thomas J. Semrad, MD, assistant professor, co-director, Phase I Program, UC Davis Health System, discusses the Serial Patient-Derived Xenografts to Understand Cancer Therapy Resistance (SPIDER) program at UC Davis Health System, aimed at understanding patient resistance to cancer therapies.

Researchers are working to understand the efficacy of novel targeted and immunotherapy agents, what resistance develops, and how to overcome this resistance, Semrad explains. The SPIDER program involves examining research-based tumor biopsies. A biopsy is done prior to the start of a new treatment and tumor tissue is implanted into immune-deficient mice, known as patient-derived xenografts.

These models are able to treated similarly to human patients because they are able to be recapitulated, Semrad explains. When patients develop resistance to the treatment, a second biopsy is done, as well as a second implantation of tumor tissue into another mouse model.

SELECTED
LANGUAGE


Thomas J. Semrad, MD, assistant professor, co-director, Phase I Program, UC Davis Health System, discusses the Serial Patient-Derived Xenografts to Understand Cancer Therapy Resistance (SPIDER) program at UC Davis Health System, aimed at understanding patient resistance to cancer therapies.

Researchers are working to understand the efficacy of novel targeted and immunotherapy agents, what resistance develops, and how to overcome this resistance, Semrad explains. The SPIDER program involves examining research-based tumor biopsies. A biopsy is done prior to the start of a new treatment and tumor tissue is implanted into immune-deficient mice, known as patient-derived xenografts.

These models are able to treated similarly to human patients because they are able to be recapitulated, Semrad explains. When patients develop resistance to the treatment, a second biopsy is done, as well as a second implantation of tumor tissue into another mouse model.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Addressing Post-Transplant Obstacles: Current and Emerging Strategies to Evolve the Standard of Care for Patients With Graft-Versus-Host DiseaseMar 28, 20192.0
2017 Year in Review™: Clinical Impact of Immunotherapies in the Treatment of CancerMar 30, 20191.75
Publication Bottom Border
Border Publication
x