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Dr. Skarbink on Unmet Needs for High-Risk Hematologic Malignancies

Alan Skarbnik, MD
Published: Monday, Feb 05, 2018



Alan Skarbnik, MD, staff physician, department of Bone Marrow Transplant, Department of Lymphoma, John Theurer Cancer Center, discusses unmet needs for patients with high-risk hematologic malignancies.

There is a question of how to manage patients with high-risk hematologic malignancies, according to Skarbink. The standard of care is an autologous stem cell transplant; however, most of these patients will relapse quickly. This poses the question of whether physicians should consolidate these patients further with therapy post-transplantation, including allogeneic stem cell transplantation in order to decrease the risk of relapse, or if they should be monitored further.

An approach that has been tested is lenalidomide (Revlimid) maintenance therapy post-autologous transplant in patients with multiple myeloma. Data are still questionable but it appears that it might increase progression-free survival and overall survival for these patients, explains Skarbink. The FDA has approved lenalidomide as a maintenance therapy for patients with multiple myeloma following autologous hematopoietic stem cell transplant in February 2017.
 


Alan Skarbnik, MD, staff physician, department of Bone Marrow Transplant, Department of Lymphoma, John Theurer Cancer Center, discusses unmet needs for patients with high-risk hematologic malignancies.

There is a question of how to manage patients with high-risk hematologic malignancies, according to Skarbink. The standard of care is an autologous stem cell transplant; however, most of these patients will relapse quickly. This poses the question of whether physicians should consolidate these patients further with therapy post-transplantation, including allogeneic stem cell transplantation in order to decrease the risk of relapse, or if they should be monitored further.

An approach that has been tested is lenalidomide (Revlimid) maintenance therapy post-autologous transplant in patients with multiple myeloma. Data are still questionable but it appears that it might increase progression-free survival and overall survival for these patients, explains Skarbink. The FDA has approved lenalidomide as a maintenance therapy for patients with multiple myeloma following autologous hematopoietic stem cell transplant in February 2017.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Rapid Reviews in Oncology®: Practice-Changing Data in Acute Myeloid Leukemia: A Rapid Update From Atlanta OnlineDec 21, 20182.0
Year in Review™: Reflecting on Recent Evidence for the Treatment of Hematologic MalignanciesFeb 28, 20192.0
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