Dr. Spigel Reflects on the PACIFIC Study in NSCLC

David Spigel, MD
Published: Friday, Oct 05, 2018



David Spigel, MD, chief scientific officer, director, Lung Cancer Research Program, principal investigator, Sarah Cannon Research Institute, reflects on the results of the PACIFIC trial in patients with non–small cell lung cancer (NSCLC).

Until the PACIFIC study, Spigel says that all the pivotal work over the last several years has been in the advanced stage. The PACIFIC study looked the role of immunotherapy in patients with unresectable stage III NSCLC. Findings of the study showed that durvalumab (Imfinzi) significantly improved overall survival versus placebo when used as a sequential treatment in patients with locally-advanced, unresectable NSCLC who had not progressed following standard chemoradiotherapy.

Since the discovery of concurrent chemoradiation, Spigel says that not much has been achieved by way of novel therapies for this population. This was the first time that a new therapy impacted the standard of care of chemoradiation in this setting, Spigel states.


David Spigel, MD, chief scientific officer, director, Lung Cancer Research Program, principal investigator, Sarah Cannon Research Institute, reflects on the results of the PACIFIC trial in patients with non–small cell lung cancer (NSCLC).

Until the PACIFIC study, Spigel says that all the pivotal work over the last several years has been in the advanced stage. The PACIFIC study looked the role of immunotherapy in patients with unresectable stage III NSCLC. Findings of the study showed that durvalumab (Imfinzi) significantly improved overall survival versus placebo when used as a sequential treatment in patients with locally-advanced, unresectable NSCLC who had not progressed following standard chemoradiotherapy.

Since the discovery of concurrent chemoradiation, Spigel says that not much has been achieved by way of novel therapies for this population. This was the first time that a new therapy impacted the standard of care of chemoradiation in this setting, Spigel states.



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 18th Annual International Lung Cancer Congress®Oct 31, 20181.5
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Publication Bottom Border
Border Publication
x